Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease
Identifieur interne : 000232 ( Main/Corpus ); précédent : 000231; suivant : 000233Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease
Auteurs : I. Midi ; M. Dogan ; M. Koseoglu ; G. Can ; M. A. Sehitoglu ; D. I. GunalSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2008-01.
English descriptors
Abstract
Objective – To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group. Materials and methods – Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations. Results – Compared with controls, roughness (P = 0.15), breathiness (P = 0.004) and asthenia (P = 0.031) values of males and breathiness (P = 0.043) and asthenia (P = 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (P = 0.0001 for male, P = 0.002 for female). The mean values for MPT (P = 0.02) and DDK (P = 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (P = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group. Conclusion – Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.
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DOI: 10.1111/j.1600-0404.2007.00965.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title><author><name sortKey="Midi, I" sort="Midi, I" uniqKey="Midi I" first="I." last="Midi">I. Midi</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Dogan, M" sort="Dogan, M" uniqKey="Dogan M" first="M." last="Dogan">M. Dogan</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Koseoglu, M" sort="Koseoglu, M" uniqKey="Koseoglu M" first="M." last="Koseoglu">M. Koseoglu</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Can, G" sort="Can, G" uniqKey="Can G" first="G." last="Can">G. Can</name><affiliation><mods:affiliation>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Sehitoglu, M A" sort="Sehitoglu, M A" uniqKey="Sehitoglu M" first="M. A." last="Sehitoglu">M. A. Sehitoglu</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Gunal, D I" sort="Gunal, D I" uniqKey="Gunal D" first="D. I." last="Gunal">D. I. Gunal</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A890ABD26B2E0DC358DFCB757944C22A3110B022</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1600-0404.2007.00965.x</idno><idno type="url">https://api.istex.fr/document/A890ABD26B2E0DC358DFCB757944C22A3110B022/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title><author><name sortKey="Midi, I" sort="Midi, I" uniqKey="Midi I" first="I." last="Midi">I. Midi</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Dogan, M" sort="Dogan, M" uniqKey="Dogan M" first="M." last="Dogan">M. Dogan</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Koseoglu, M" sort="Koseoglu, M" uniqKey="Koseoglu M" first="M." last="Koseoglu">M. Koseoglu</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Can, G" sort="Can, G" uniqKey="Can G" first="G." last="Can">G. Can</name><affiliation><mods:affiliation>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Sehitoglu, M A" sort="Sehitoglu, M A" uniqKey="Sehitoglu M" first="M. A." last="Sehitoglu">M. A. Sehitoglu</name><affiliation><mods:affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Gunal, D I" sort="Gunal, D I" uniqKey="Gunal D" first="D. I." last="Gunal">D. I. Gunal</name><affiliation><mods:affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-01">2008-01</date><biblScope unit="volume">117</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="26">26</biblScope><biblScope unit="page" to="34">34</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">A890ABD26B2E0DC358DFCB757944C22A3110B022</idno><idno type="DOI">10.1111/j.1600-0404.2007.00965.x</idno><idno type="ArticleID">ANE965</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>Unified Parkinson’s Disease Rating Scale</term><term>voice analysis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective – To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group. Materials and methods – Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations. Results – Compared with controls, roughness (P = 0.15), breathiness (P = 0.004) and asthenia (P = 0.031) values of males and breathiness (P = 0.043) and asthenia (P = 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (P = 0.0001 for male, P = 0.002 for female). The mean values for MPT (P = 0.02) and DDK (P = 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (P = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group. Conclusion – Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>I. Midi</name><affiliations><json:string>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>M. Dogan</name><affiliations><json:string>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>M. Koseoglu</name><affiliations><json:string>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>G. Can</name><affiliations><json:string>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>M. A. Sehitoglu</name><affiliations><json:string>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>D. I. Gunal</name><affiliations><json:string>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>voice analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Unified Parkinson’s Disease Rating Scale</value></json:item></subject><articleId><json:string>ANE965</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objective – To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group. Materials and methods – Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations. Results – Compared with controls, roughness (P = 0.15), breathiness (P = 0.004) and asthenia (P = 0.031) values of males and breathiness (P = 0.043) and asthenia (P = 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (P = 0.0001 for male, P = 0.002 for female). The mean values for MPT (P = 0.02) and DDK (P = 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (P = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group. Conclusion – Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>2146</abstractCharCount><pdfWordCount>5022</pdfWordCount><pdfCharCount>32648</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>308</abstractWordCount></qualityIndicators><title>Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>117</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>9</total><last>34</last><first>26</first></pages><issn><json:string>0001-6314</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1600-0404.2007.00965.x</json:string></doi><id>A890ABD26B2E0DC358DFCB757944C22A3110B022</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A890ABD26B2E0DC358DFCB757944C22A3110B022/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A890ABD26B2E0DC358DFCB757944C22A3110B022/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A890ABD26B2E0DC358DFCB757944C22A3110B022/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title><author><persName><forename type="first">I.</forename><surname>Midi</surname></persName><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation></author><author><persName><forename type="first">M.</forename><surname>Dogan</surname></persName><affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</affiliation></author><author><persName><forename type="first">M.</forename><surname>Koseoglu</surname></persName><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation></author><author><persName><forename type="first">G.</forename><surname>Can</surname></persName><affiliation>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</affiliation></author><author><persName><forename type="first">M. A.</forename><surname>Sehitoglu</surname></persName><affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</affiliation></author><author><persName><forename type="first">D. I.</forename><surname>Gunal</surname></persName><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-01"></date><biblScope unit="volume">117</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="26">26</biblScope><biblScope unit="page" to="34">34</biblScope></imprint></monogr><idno type="istex">A890ABD26B2E0DC358DFCB757944C22A3110B022</idno><idno type="DOI">10.1111/j.1600-0404.2007.00965.x</idno><idno type="ArticleID">ANE965</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective – To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group. Materials and methods – Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations. Results – Compared with controls, roughness (P = 0.15), breathiness (P = 0.004) and asthenia (P = 0.031) values of males and breathiness (P = 0.043) and asthenia (P = 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (P = 0.0001 for male, P = 0.002 for female). The mean values for MPT (P = 0.02) and DDK (P = 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (P = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group. Conclusion – Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson’s disease</term></item><item><term>voice analysis</term></item><item><term>Unified Parkinson’s Disease Rating Scale</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A890ABD26B2E0DC358DFCB757944C22A3110B022/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/ane.2008.117.issue-1</doi><numberingGroup><numbering type="journalVolume" number="117">117</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2008-01">January 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1600-0404.2007.00965.x</doi><idGroup><id type="unit" value="ANE965"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1"><i>Original articles</i></title></titleGroup><eventGroup><event type="firstOnline" date="2007-11-20"></event><event type="publishedOnlineFinalForm" date="2007-11-20"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText" date="2014-11-13"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="26">26</numbering><numbering type="pageLast" number="34">34</numbering></numberingGroup><correspondenceTo>Ipek Midi, Department of Neurology, Marmara University Hospital, Tophanelioglu Cad. No: 13‐15 Altunizade‐Uskudar‐Istanbul, Turkey
Tel.: +90 2163271010/266
Fax: +90 2163259777
e‐mail: <email>ipekmidi@yahoo.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE965.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication October 12, 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title><title type="shortAuthors"><b>Midi et al.</b></title><title type="short"><b>Voice and its relation with motor function in Parkinson's disease</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>I.</givenNames><familyName>Midi</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>M.</givenNames><familyName>Dogan</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>M.</givenNames><familyName>Koseoglu</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>G.</givenNames><familyName>Can</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>M. A.</givenNames><familyName>Sehitoglu</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>D. I.</givenNames><familyName>Gunal</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="TR"><unparsedAffiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="TR"><unparsedAffiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="TR"><unparsedAffiliation>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="TR"><unparsedAffiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson’s disease</keyword><keyword xml:id="k2">voice analysis</keyword><keyword xml:id="k3">Unified Parkinson’s Disease Rating Scale</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Midi I, Dogan M, Koseoglu M, Can G, Sehitoglu MA, Gunal DI. Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease.
Acta Neurol Scand 2008: 117: 26–34.
© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. --><p><b>Objective – </b> To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group.</p><p><b>Materials and methods – </b> Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations.</p><p><b>Results – </b> Compared with controls, roughness (<i>P </i>=<i> </i>0.15), breathiness (<i>P </i>=<i> </i>0.004) and asthenia (<i>P = </i>0.031) values of males and breathiness (<i>P </i>=<i> </i>0.043) and asthenia (<i>P </i>= 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (<i>P</i> = 0.0001 for male, <i>P</i> = 0.002 for female). The mean values for MPT (<i>P = </i>0.02) and DDK (<i>P =</i> 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (<i>P</i> = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group.</p><p><b>Conclusion – </b> Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Voice and its relation with motor function in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Midi</namePart><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Dogan</namePart><affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Yeditepe University Hospital, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Koseoglu</namePart><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Can</namePart><affiliation>Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Sehitoglu</namePart><affiliation>Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. I.</namePart><namePart type="family">Gunal</namePart><affiliation>Department of Neurology, Marmara University Hospital, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-01</dateIssued><edition>Accepted for publication October 12, 2007</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent></physicalDescription><abstract lang="en">Objective – To evaluate changes in perceptual and several acoustic parameters of voice in patients with Parkinson’s disease (PD) and to find out any relation with these parameters and motor components of Unified Parkinson’s Disease Rating Scale (UPDRS) in this patient group. Materials and methods – Twenty patients with PD (12 male and 8 female) were given objective and subjective voice tests and results were compared with those of 20 age‐ and sex‐matched controls. Patient's perceptual voice analysis was assessed using GRBAS scale including Grade of Dysphonia, Roughness, Breathiness, Asthenia and Strain items. Measurements for objective voice analysis, acoustic assessment tests including frequency perturbation [jitter (jitt)%], intensity perturbation [shimmer (shim)%], noise to harmonic ratio (NHR), fundamental frequency (F0), variability of fundamental frequency (vF0), diadochokinetic rate (DDK) and maximum phonation time (MPT) were used. An assessment of disability caused by voice disorders was scored according to the Voice Handicap Index (VHI) by the patient. All subjects also underwent videolaryngostroboscopic (VLS) examination. Motor components of UPDRS and acoustic parameters of voice were investigated for any correlations. Results – Compared with controls, roughness (P = 0.15), breathiness (P = 0.004) and asthenia (P = 0.031) values of males and breathiness (P = 0.043) and asthenia (P = 0.023) values of females were higher in patients with PD. Mean VHI scores of patients with PD were higher for both male and female patients (P = 0.0001 for male, P = 0.002 for female). The mean values for MPT (P = 0.02) and DDK (P = 0.025) were shorter in patients with PD. Jitt%, shim% and mean F0 values were similar among the two groups. But mean vF0 values were significantly higher in male patients with PD (P = 0.05). On VLS examination, non‐closure glottic pattern was found to be more frequent in the PD group. Conclusion – Although it is well known that pathophysiological changes in PD affect the voice, the present study found only few significant correlations between motor component of UPDRS and voice parameters.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson’s disease</topic><topic>voice analysis</topic><topic>Unified Parkinson’s Disease Rating Scale</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>26</start><end>34</end><total>9</total></extent></part></relatedItem><identifier type="istex">A890ABD26B2E0DC358DFCB757944C22A3110B022</identifier><identifier type="DOI">10.1111/j.1600-0404.2007.00965.x</identifier><identifier type="ArticleID">ANE965</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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